Acid-base events during hemodialysis

Disturbances in Acid-Base Balance in Patients on Hemodialysis

The prevalence of metabolic acidosis increases in Chronic Kidney Disease (CKD) patients ac‐ cording to the fall in glomerular filtration rate (GFR). In early stages of renal dysfunction acid retention is mainly due to the reduced tubular ammonium (NH4+) secretion. As GFR de‐ clines retention of organic acids (HSO4, HPO4) is also observed. The acid load resultant from diet and protein catabolism...

The effect of hemodialysis on electrolytes and acid-base parameters.

BACKGROUND Hemodialysis patients are treated with bicarbonate dialysate to correct the metabolic acidosis, which results from the metabolism of dietary and endogenous protein. The concentration of plasma tCO(2) is used to gauge the success of therapy. Reported low values in pre-dialysis blood suggest incomplete correction of acidosis in a substantial percent of the dialysis population. However,...

2,3-Diphosphoglyceric Acid Changes in Uremia and During Hemodialysis

Acid-base.

Acid-base disorders are common clinical problems resulting from a wide variety of pathophysiological conditions, including newly recognised acquired and genetic causes. The history and physical examination and measurement of blood and urinary indices allow identification of the underlying cause of these disorders in most cases. Treatment directed at correction of electrolyte abnormalities and t...

Beyond bicarbonate: complete acid-base assessment in patients receiving intermittent hemodialysis.

Background Acid-base assessments in hemodialysis patients have been limited almost entirely to measurements of total CO 2 concentration, and assumptions have been made about the presence of acid-base disorders. To gain a fuller understanding of the acid-base status of stable hemodialysis patients, we analyzed measurements of pCO 2 , pH and HCO 3 - obtained in a cohort of chronic stable hemodial...